Alfred L. M. Bothwell, PhD
Professor of Immunobiology; Director of Graduate Studies
Departments & Organizations
Biomedical EthicsBiological and Biomedical Sciences (BBS): Immunology: Computational Immunology | Molecular Cell Biology, Genetics and Development
Cancer Immunology
Vascular Biology and Therapeutics Program
Immunobiology
Diabetes Endocrinology Research Center
Immunology and Immunotherapy
Research Interests
Human T cell recognition; inflammation and cancer; type 1 diabetes; function of PPARs
Clinical Interests
Studies of human T cell recognition of human endothelial cells. The research goals of the Bothwell lab are to characterize the development and function of T cells and to characterize mechanisms that affect T cell recognition and recruitment into vascular sites. In addition, humanized mouse models are being established to study type 1 diabetes and breast cancer.
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Education
- BA, Washington University, 1971
- Ph.D., Yale University, 1975
Selected Publication
- Tobiasova, Z., Zhang, L., Yi, T., Qin, L., Kulkarni, S., Rodriguez, F., Choi, J.-M., Tellides, G., Pober, J.S., Kawikova, I. and Bothwell, A.L.M. (2011). PPAR? agonists prevent in vivo remodeling of human artery induced by alloreactive T cells. Circulation 124:196-205.
Articles
Jan/Feb 2010
Autoimmunity: research on many fronts
Inflammatory bowel disease (IBD)IBD is a group of inflammatory conditions of the colon and small intestine that...
Oct/Nov 2005
Grants and contracts awarded to Yale School of Medicine
FederalVikki Abrahams, NIH, Innate Immune Responses of Trophoblasts in Pregnancy, 5 years, $1,375,632Anton Bennett,...
Medicine@Yale, the bimonthly newsletter of Yale School of Medicine (YSM), chronicles achievements
of YSM in basic and clinical research, medical education, and health care. Read More...
