Grants and contracts awarded to Yale School of Medicine

September/October, 2010


Federal

  • Hervé Agaisse, NIH, Host Factors Involved in Listeria monocytogenesSpread from Cell to Cell, 9 months, $413,305
  • Sandra Alfano, NIH, Promoting and Developing Human Research Protection Programs in International Settings, 1 year, $53,726 
  • Frederick Altice, NIH, Prison Interventions and HIV Prevention Collaboration, 5 years, $2,195,538 
  • George Anderson, Department of Defense, Biomarkers for Autism and for Gastrointestinal and Sleep Problems in Autism, 3 years, $472,129 
  • Marcus Bosenberg, Department of Defense, UVL, ROS, Pigmentation, Genetic Predisposition, and Epigenetic Gene Silencing in Melanoma, 3 years, $381,886
  • Douglas Brash, Department of Defense, UVL, ROS, Pigmentation, Genetic Predisposition, and Epigenetic Gene Silencing in Melanoma, 3 years, $540,363
  • Catalin Buhimschi, NIH, DAMP-RAGE Signaling and Fetal Injury in Inflammation-Induced Preterm Birth, 5 years, $1,989,170
  • Lloyd Cantley, NIH, Center for Polycystic Kidney Research at Yale, 5 years, $1,517,657 
  • Michael Caplan, NIH, Center for Polycystic Kidney Research at Yale, 5 years, $2,621,551
  • Sandy Chang, NIH, Telomere-Induced Senescence as a Suppressor of Tumorigenesis, 2 years, $793,777 
  • John Chidlow, NIH, Physiological Regulation of Vascular Function by Mutant Caveolin-1, 3 years, $143,670
  • Mark Cicero, Health Resources and Services Administration/DHHS,Small Victims, Big Challenges: Refining Pediatric Disaster Triage Education and Assessing Triage Algorithms in the Pre-hospital Setting, 3 years, $852,415
  • Robert Constable, NIH, Null Spacing Imaging: A Novel Approach to Accelerating MR Imaging, 5 years, $3,461,146
  • Larry Davidson, NIH, Effectiveness and Cost-Effectiveness of Peer Mentors in Reducing Hospital Use, 4 years, $3,701,164
  • Isabelle Derre, NIH, Identification of Human Host Factors Involved in Chlamydia Development, 2 years, $455,229
  • Francesco D’Errico, National Science Foundation, Superheated Emulsions for Nuclear Material Detection, 1 year, $389,180
  • James Duncan, NIH, Extraction of Functional Subnetworks in Autism Using Multimodal MRI, 1 year, $384,865
  • John Elsworth, NIH, Dopamine Modulation of Cortical Spine Synapses and Cognition in MPTP Monkeys, 5 years, $2,338,028
  • Richard Flavell, NIH, Understanding Hematopoietic Neoplasias using Humanized Mice, 5 years, $5,444,073 
  • Amanda Foust, NIH, Optical Imaging of Information Processing in CNS Axons, 3 years, $115,840 
  • Thomas Gill, NIH, Epidemiology of Disability and Recovery in Older Persons, 5 years, $4,503,758 
  • Bonnie Gould Rothberg, NIH, Prognostic Markers in Metastatic Melanoma, 5 years, $530,195 
  • Eduardo Groisman, NIH, Regulation ofSalmonella Virulence by the PhoP Protein, 6 months, $248,250; NIH, Molecular and Functional Analyses of the PMRA/PMRB Regulatory System, 3 years, $997,641
  • David Hafler, NIH, Regulatory T Cells in Autoimmune Disease, 1 year, $848,779 
  • Ruth Halaban, Department of Defense, UVL, ROS, Pigmentation, Genetic Predisposition, and Epigenetic Gene Silencing in Melanoma, 3 years, $273,752
  • Robert Heimer, NIH, Influences on HIV Prevalence and Service Access among IDUS in Russia and Estonia, 5 years, $1,775,423
  • Kevan Herold, NIH, Human and Translational Immunology, 5 years, $1,043,354; NIH, Innate and Adaptive Immune Responses in Pre–Type 1 Diabetes, 2 years, $399,089
  • Raimund Herzog, NIH, Adaptations of Brain Energy Metabolism to Hypoglycemia, 5 years, $776,520
  • Christopher Hoimes, Department of Defense, Engineered Histone Deacetylase Inhibitor Nanoparticles for Durable Suppression of Androgen Receptor Target Genes in Prostate Cancer, 2 years, $119,792
  • Tamas Horvath, NIH, Hypothalamic AgRP Neurons are Determinants of Healthy Lifespan and Higher Brain Functions, 5 years, $4,130,467
  • Leora Horwitz, NIH, Heart Failure Readmissions in Older Adults: A Systems Perspective, 4 years, $648,465 
  • Akiko Iwasaki, NIH, Antiviral CTL Mobilization to the Genital Mucosa, 2 months, $403,434 
  • Kenneth Kidd, Department of Justice, Developing a Forensic Resource/Reference on Genetics Knowledge Base, 2 years, $643,771 
  • In-Jung Kim, NIH, Molecular Specification of Direction Selectivity in the Visual System, 3 years, $747,000
  • Peter Krause, Centers for Disease Control and Prevention/DHHS,Lyme Disease Reduction Via Deer-Targeted Interventions, 1 year, $95,000 
  • Harlan Krumholz, NIH, Center for Cardiovascular Outcomes Research at Yale University, 4 years, $6,817,443
  • Chandrika Kumar, Health Resources and Services Administration/DHHS, Medical Resident Rotation in Ambulatory Geriatrics, 5 years, $374,955
  • Robert Leeman, NIH, Difficulties with Self-Control and High-Risk Alcohol Use in Young Adults, 5 years, $750,033
  • Judith Lichtman, Centers for Disease Control and Prevention/DHHS,Cardiovascular Disease Trends in Elderly, 8 months, $45,000 
  • Haifan Lin, NIH, Toward a Central Question on Epigenetics: A Major Epigenetic Programming Mechanism Guided by piRNAs, 5 years, $4,150,417 
  • Elias Lolis, NIH, Crystal Structures of CXCR4 Complexed to CXCL12, 2 years, $455,125 
  • Shuangge Ma, NIH, Novel Methods for Integrative Analysis of Cancer Genomic Data, 4 years, $1,344,185
  • Ruslan Medzhitov, NIH, Integration of Cytokine Receptors and Immunoreceptors Signaling Pathways, 1 year, $413,750
  • Joshua Motelow, NIH, Subcortical Control of Neocortical Slowing During Focal Hippocampal Seizures, 3 years, $138,225 
  • Terrence Murphy, NIH, Enhanced Evaluation of Second Stage Translational Research(EESTR), 9 months, $232,001
  • Rafael Perez-Escamilla, NIH, Stress Management Among Latinos with Type 2 Diabetes, 5 years, $1,725,273
  • Scott Rivkees, NIH, Graves’ Disease Therapy Risks to Mother and Fetus, 4 years, $2,562,440
  • Carla Rothlin, NIH, TAM Receptor Tyrosine Kinases in Inflammatory Bowel Disease, 4 years, $1,632,874
  • Gerald Shulman, NIH, Genetic and Cellular Mechanisms of NAFLD and Hepatic Insulin Resistance, 5 years, $7,143,910 
  • Albert Sinusas, NIH, Training in Multi-Modality Molecular and Translational Cardiovascular Imaging, 5 years, $1,182,836 
  • Megan Smith, Department of Health and Human Services, New Haven Mental Health Outreach for Mothers(MOMSProject 4, 1 year, $100,000 
  • Dieter Söll, Department of Energy, Engineering Selenoproteins for Enhanced Hydrogen Production, 3 years, $581,935 
  • Stefan Somlo, NIH, Center for Polycystic Kidney Research at Yale, 5 years, $1,529,318 
  • Sandra Springer, NIH, Naltrexone for Opioid Dependent Released HIV+ Criminal Justice Populations, 5 years, $4,213,200
  • Eugene Swenson, NIH, Investigation of the Liver Progenitor Cell Niche Using CK19 Lineage Tracing, 2 years, $165,500 
  • Michal Tal, NIH, A Role for Autophagy in Cytosolic Viral Recognition and Aging, 2 years, $67,480 
  • Mary Tinetti, Agency for Healthcare Research and Quality/DHHS, Beta-Blocker Effect on a Range of Health Outcomes in Older Adults with CAD and COPD, 1 year, $361,109
  • Adam Trexler, NIH, Single-Molecule Fluorescence to Characterize Alpha Synuclein Transition to Toxic Oligomeric States, 2 years, $82,760
  • Xiao-Jing Wang, NIH, CRCNS: Uncovering Neural Circuit Mechanisms of Category Computation and Learning, 5 years, $1,664,436 
  • Scott Weatherbee, NIH, Center for Polycystic Kidney Research at Yale, 5 years, $82,750
  • John Wysolmerski, NIH, PTHrP in Mammary Development, 4 years, $1,406,750
  • Xiaoyong Yang, NIH, O-GlcNAc Modification in Metabolic Homeostasis, 5 years, $2,068,750
  • Hongyu Zhao, NIH, Loss-of-Function Variants in the 1000 Genomes Data Set and Implications for GWAS, 2 years, $732,963

Non-Federal

  • Nancy Angoff, American Medical Association Foundation, Food, Medicine, and Wellness Event, 7 months, $400
  • Richard Belitsky, Gilead Foundation, HAVEN Primary Care Clerkship, 1 year, $69,382
  • Benjamin Blagogee, American College of Occupational and Environmental Medicine, Injury and Return to Work Issues among Truck and Bus Drivers, 1 year, $35,439
  • Hal Blumenfeld, Children’s Hospital (Cincinnati), Impact of Initial Therapy and Response on Long-Term Outcome in Children with CAE, 1 year, $8,801
  • Angelique Bordey, Connecticut Innovations, Inc., Mechanical Control of Neural Stem Cell Fate, 4 years, $928,954
  • Elizabeth Bradley, Bill and Melinda Gates Foundation, Diffusion, Dissemination and Widespread Take up: What Works?, 1 year, $362,571; Doris Duke Charitable Foundation, Global Health Leadership Institute Conference, 1 year, $25,000
  • Peter Broer, Plastic Surgery Educational Foundation, The Role of Leptin in Calciphylaxis, 1 year, $9,500
  • Ketan Bulsara, Micrus Endovascular Corporation, Micrus PAC Trial: Evaluation of Presidio and Cerecyte Coils in Large and Giant Aneurysms, 1 year, $21,790
  • Herta Chao, William O. Seery Foundation, Imaging the Effects of R-CHOP Chemotherapy on Cognitive Function in Patients with CD20-Positive High-Grade Lymphoma, 1 year, $68,000
  • Ee-Chun Cheng, Connecticut Innovations, Inc., The Role of Epigenetic Factor HP1 in Regulating Human Embryonic Stem Cell Pluripotency and Differentiation, 2 years, $200,000
  • Daniel Colón-Ramos, Alfred P. Sloan Foundation, Molecular Factors Directing Synaptic Specificity in theC. elegans Brain, 2 years, $50,000
  • Sukru Emre, University of Texas Southwestern Medical Center at Dallas, A Multi-Center Group to Study Acute Liver Failure, 1 year, $95,153
  • Adrienne Ettinger, University of New Mexico, A Prospective Birth Cohort Study Involving Uranium Exposure in the Navajo Nation, 1 year, $24,908
  • Richard Flavell, U.S.-Israel Binational Science Foundation, Elucidation of Leptin’s Immuno-modulatory Effects on the Gastrointestinal Immune Response, 2 years, $49,700; Connecticut Innovations, Inc.,Characterization of Human Hematopoiesis in vivoin an Improved Model of Humanized Mice Engrafted with Embryonic Stem Cell-Derived Hematopoietic Stem Cells, 5 months, $1,000,000; Bill and Melinda Gates Foundation, A Mouse Model for Human Malaria Infection, 2 years, $2,983,165
  • Richard Formica, Mount Sinai School of Medicine, Individualizing Therapy for Kidney and Heart Transplant Recipients, 1 year, $190,850
  • Gigi Galiana, L’Oréal USA, Faster MRI with a B1 Accelerated Reconstruction Sequence (BARS), 1 year, $60,000
  • Xiao-Bing Gao, Foundation for Prader-Willi Research, MCH Neurons in Prader-Willi Syndrome Animal Models, 1 year, $50,000
  • Xin Quan Ge, Connecticut Innovations, Inc., The Role of Dormant Organs in Ensuring Genome Integrity in Human Embryonic Stem Cells, 2 years, $200,000 
  • Joel Gelernter, Medical University of South Carolina, Exploration of GxE Interactions for PTSD in Disaster-Affected Youth, 1 year, $104,006
  • Frank Giordano, Angion Biomedica Corp., SBIR: A Phase II Pilot Study to Evaluate the Safety and Activity of BB3 as an Adjunct to Percutaneous Coronary Intervention(PCIin Subjects Presenting with Acute ST Segment Elevation MI (STEMI), 2 years, $1,188,559 
  • John Giuliano Jr., Children’s Hospital of Philadelphia, Multi-Center NEAR4KIDS, 7 months, $1,000
  • Daniel Greif, Pulmonary Hypertension Association, Morphogenesis of the Pulmonary Artery Smooth Muscle Layer, 3 years, $203,521 
  • Cary Gross, Dana Farber Cancer Institute, Accountability and the Role of the Principal Investigator in Multicenter Trials, 9 months, $15,925 
  • Caren Gundberg, Rensselaer Polytechnic Institute, Effects of Osteocalcin and Osteopontin on Damage Morphology and Bone Fragility, 5 years, $209,314
  • David Hafler, Brigham and Women’s Hospital, Project 4 Analysis of Pathogenic T Cell Response in MS, 1 year, $62,755; Dana Farber Cancer Institute, Antigen Presentation in Human Autoimmune Diseases (Project 4), 1 year, $332,868; Massachusetts Institute of Technology, Analytical Microtools for Discovering Autoreactive Lymphocytes, 1 year, $133,500; University of California, San Francisco, A Haplotype Map for Multiple Sclerosis, 7 months, $116,200
  • Lyndsay Harris, Breast Cancer Research Foundation, Biomarker Incubator to Define and Validate Predictors of Response to Paclitaxel and Trastuzumab, 1 year, $222,982
  • Erica Herzog, American Thoracic Society, Semaphorin 7A and Alternative Macrophage Activation in IPF, 2 years, $100,000 
  • Raimund Herzog, Rockefeller University, The Role of GSAP in the Pathophysiology of Type 2 Diabetes Mellitus, 7 months, $15,000
  • Theodore Holford, Pacific Institute for Research and Evaluation, Lung Cancer Group for NCI’s CISNET Program, 1 year, $79,314
  • Leora Horwitz, American Federation for Aging Research, AFAR, 4 years, $99,968 
  • Changyun Hu, Juvenile Diabetes Research Foundation International,Anti-CD20 and Oral Anti-CD3 Prevents and Reverses Diabetes in NOD Mice, 3 years, $246,048 • 
  • Steven Kleinstein, U.S.-Israel Binational Science Foundation, Modeling Competition and Genetic Diversification in Adaptive Immunity, 4 years, $82,350; Mount Sinai School of Medicine, Program for Research on Immune Modeling and Experimentation(PRIME), 5 years, $1,284,931
  • Diane Krause, Connecticut Innovations, Inc., Use of Human Embryonic Stem Cells and Inducible Pluripotent Stem Cells to Study Megakaryoblastic Leukemia, 3 years, $2,000,000 
  • Gary Kupfer, U.S.-Israel Binational Science Foundation, Analysis of Congenital Dyserythropoietic Anemia (CDAThrough Creation and Manipulation of Patient-Derived Induced Pluripotent Stem Cells, 4 years, $53,500
  • Alexandra Lansky, Nakuuruq Solutions, LLC, Women’s Heart Health Awareness, 1 year, $127,500
  • Eun Jung Lee, Connecticut Innovations, Inc., Maturation of Human Embryonic Stem Cell(HESC)-Derived Cardiomyocytes In VivoUsing 3D Engineered Tissue Model System, 2 years, $200,000
  • Ben Lin, American Society of Echocardiography, Analysis of Regional Myocardial Strain and Vortical Flow Dynamic as Predictors of Left Ventricular Remodeling after Infarction, 1 year, $35,000
  • Haifan Lin, Ellison Medical Foundation, piwi-piRNA Mechanism in Maintaining Genome Integrity and Longevity, 4 years, $993,000
  • Shuangge Ma, University of Texas Southwestern Medical Center at Dallas, Predicting Adjuvant Chemotherapy Responses in Lung Cancer, 5 months, $20,159
  • Robert Makuch, IMD Marketing Consulting Co., Ltd., Yale University: Crisis Management Training, 2 months, $49,800; IMD Marketing Consulting Co., Ltd, Yale University: Hospital Management Training, 1 year, $22,025
  • Pramod Mistry, National Gaucher Foundation, Mechanism of Gaucher Disease in a New Conditional KO Mouse Model of Type 1 Gaucher Disease, 1 year, $70,000
  • Gil Mor, U.S.-Israel Binational Science Foundation, Preparation of the Uterus for Implantation, 4 years, $32,000 
  • Angus Nairn, Rockefeller University, Functional Analysis of Signaling Proteins in Dendritic Spines, 5 years, $1,298,988
  • Don Nguyen, V Foundation for Cancer Research, Tumor–Microenvironment Interactions That Regulate the Therapeutic Response of Lung Cancer Brain Metastasis, 2 years, $200,000
  • Elaine O’Keefe, Boston University, CT Partnership for Public Health Workforce Development, 5 years, $700,000
  • Efrat Oron, Connecticut Innovations, Inc., Molecular Mechanisms of Germ Layer Induction in Human Embryonic Stem Cells, 2 years, $200,000
  • Michael Paidas, Talecris Biotherapeutics, Inc., Antithrombin Levels Preceding Placenta-Mediated Complications, 1 year, $236,460
  • Lori Post, Michigan State University, Health Information Technology to Prevent Abuse, Neglect, and Exploitation, 1 year, $83,906 
  • Caihong Qiu, Connecticut Innovations, Inc., Regulations of Lin28 in Human Embryonic Stem Cell Self-renewal and Differentiation, 3 years, $750,000; Connecticut Innovations, Inc., Efficient Gene Targeting in Human Embryonic Stem Cells via Recombineering-Based Long Arm Targeting Vector, 2 years, $200,000
  • Peter Rabinowitz, Mary Imogene Bassett Hospital, Infection Risk in Swine Workers, 1 year, $14,999
  • David Rimm, University of Michigan, Automated Quantitated Analyses of Epidermal Growth Factor Receptor, HER2, HER3, HER4, and PTEN in N9831 Primary Breast Tumors Using Tissue Microarrays, 1 year, $50,000
  • Lawrence Rizzolo, Connecticut Innovations, Inc., Co-Differentiation of kesc-Derived Retinal and Retinal Pigment, 3 years, $832,608 
  • Matthew Rodeheffer, Connecticut Innovations, Inc., Identification and Characterization of Multipotent Cell Populations from Human Adipose Tissue for Application in Regenerative Therapies, 2 years, $200,000
  • Erik Shapiro, Connecticut Innovations, Inc., In Vivo Evaluation of Human ES, IPS and Adult Brain–Derived Neural Progenitor Cell Transplantation and Migration Using MRI, 2 years, $200,000
  • Gordon Shepherd, University of California, San Diego, Operation, Support, and Enhancement of Neuroscience Information Framework, 1 year, $214,000
  • Arthur Simen, American Foundation for Suicide Prevention, Prefrontal and Genetic Determinants of Suicidality and Depression in the Elderly with Cardiac Disease, 2 years, $75,000
  • Dieter Söll, Boston University, 2-Selenouridine Formation in Archaea, 1 year, $16,550 
  • Serena Spudich, Washington University in St. Louis, Neurological AIDS Research Consortium, 1 year, $33,100
  • Stephen Strittmatter, Association for Frontotemporal Dementias,Imaging the Role of Progranulin Interaction with Sortilin in Fronto-Temporal Lobar Degeneration, 1 year, $60,000
  • Scott Strobel, Howard Hughes Medical Institute, Rainforest Expedition and Laboratory: Engaging Undergraduate Students in Research Through Project Ownership, 4 years, $600,000
  • Joann Sweasy, University of Vermont, Structure and Function of DNA Repair Enzymes, 5 years, $251,840
  • William Tamborlane, Juvenile Diabetes Research Foundation International, InsuPatch: A Novel Approach to Accelerate Insulin Absorption and Action, 1 year, $585,341 
  • Mary Tinetti, Research Foundation for Mental Hygiene, Health and Aging Policy Fellows Application, 1 year, $132,000
  • Li Wen, Juvenile Diabetes Research Foundation International, Role of Intestinal Segmented Filamentous Bacteria in Diabetes Development, 1 year, $110,000
  • Herbert Yu, Albert Einstein College of Medicine, Serum Levels of EGFR-Signaling-Network, 1 year, $65,080