Frederick J. Sigworth PhD

Professor of Cellular and Molecular Physiology and of Biomedical Engineering and of Molecular Biophysics and Biochemistry


Fred Sigworth studied applied physics at Caltech and was a graduate student at Yale, working in the neuroscience laboratory of Charles F. Stevens. He received the PhD in physiology from Yale in 1979 and was a postdoc in the laboratory of Erwin Neher in Göttingen, Germany where he was a co-developer of patch-clamp techniques for single-channel electrophysiology. He returned to Yale as a faculty member at Yale in 1984. His current research is in the structural biology of ion-channel proteins, making use of novel cryo-EM methods. "How do I see the scientific enterprise? An old book puts it this way: one generation commends God's works to another. It is a great privilege to unravel the workings of ion channels, and to pass on the excitement about these molecular machines to students, colleagues and anyone else who will listen!"