MuratGunelmurat_gunel65477murat.gunel@yale.eduMale2015-10-08T20:34:03.867036590MG2381073594073MD209FACS135FAHA13610153459247438.96374535.2433226TurkeyProfessor Gunel conducts collaborative work in Turkey on neurovascular surgery2008-01-01T00:00:00Neurovascular Surgery116838.96374535.2433226TurkeyCollaboration on genetics of malformations of brain development2007-01-01T00:00:00Molecular GeneticsDr. Murat Gunel, Professor of Neurosurgery, assumed the position of chief of Neurovascular Surgery Program in January of 2001. Dr. Gunel is a board certified neurosurgeon and is a fellow of the American College of Surgeons. He has special interest in treating brain aneurysms and vascular malformations with special emphasis on arterio-venous malformations and cavernous malformations. He also has expertise in occlusive vascular disorders such as carotid disease and gamma knife surgery (radiosurgery). <br /><br />His laboratory interests parallel his expertise in clinical neurovascular surgery and focus on gene discovery in disorders of the nervous system and its vasculature. Dr. Gunel's lab completed the two largest genome wide association studies (GWAS) aimed at understanding common variants that underlie intracranial aneurysm genetic risk based on the analysis of over 20,000 subjects. In addition, he is interested in the identification of genes important in human brain development through the study of rare, consanguineous families with recessive forms of malformations of cortical development.64AB of Neurological Surgery2022-12-31T00:00:002002-06-12T00:00:002013-01-01T00:00:00Neurological Surgery UniversityIstanbul41.008237628.978358899999989953İstanbulTurkey203737209620378520442037372096truetruetruefalsefalsefalsefalsefalseHonorary Doctor of Philosophy DegreeBahcesehir University, Turkey23438-97United States5International Award (Awarded outside the United States)2010-09-27T00:00:002812Outstanding Scientific Achievement AwardMinister of Health, Turkey23438-97United States5International Award (Awarded outside the United States)2010-01-01T00:00:002816Outstanding Poster Award in Basic Science 5th Annual Meeting of the AANS/CNS Section of Cerebrovascular Surgery23438-97United States4National Award (United States only)2002-10-02T00:00:00778Outstanding Poster Award in Basic Science4th Annual Meeting of the AANS/CNS Section of Cerebrovascular Surgery23438-97United States4National Award (United States only)2001-10-02T00:00:00779 Young Investigator AwardAmerican Epilepsy Society23438-97United States4National Award (United States only)1999-01-01T00:00:00780Nixdorff-German ProfessorYale University23438-97United States1Yale School of Medicine Award2009-12-04T00:00:002814Honorary Master of Arts Privatim DegreeYale University23438-97United States2Yale University Award2010-01-01T00:00:002815FACfalsefalsePO Box 208082New Haven23438-97United States263506520-8082CT190414672Media Library VideoDr. Murat Gunel Is Appointed the Nixdorff-German Professor Scan Finds Link across Array of Childhood Brain Disorders-NINDS the Genetic Landscape of Brain Tumors Library VideoMassive Yale-Led Genome Analysis Reveals New Genetic Risks for Aneurysms Library VideoNixdorff-German Professor is neurosurgeon and geneticist Library VideoYale Researchers Unravel Mystery of Brain Aneurysms of Cooperative Research114820ActiveInternal ServiceProfessor24603SSecondaryfalseFAC2014-07-01T00:00:00truefalseEducation1Patient Care3Genetics10885420373710912154203785264939002037852660390520378572276692Fax2ActiveAcademic Department Lab115473ActiveLabtruefalsePatient Care3Neurovascular Surgery10939020373720962355ActiveCreated Section Care3Brain Aneurysm & AVM Program10979920373720962358Information and appointments10ActiveProgram/CentertruefalseEducation1Research2Patient Care3Neurosurgery10885520378522743574203785227635802037852285358320378541615094ActiveAcademic Department Tumor Research113695ActiveResearch Program/CentertruefalsePatient Care3Gamma Knife Center, Yale-New Haven10938920320020201688Information and appointments1087792534267718ActiveProgram/Center InterestfalsefalseResearch2Molecular/Cellular Neuroscience109919ActiveResearch InterestfalsefalseResearch2Neural Disorders109921ActiveResearch InterestfalsefalseEducation1Neuroscience109537ActiveCreated Section Cell Biology, Genetics and Development109539ActiveCreated Section Combined Program in the Biological and Biomedical Sciences (BBS)1095322037853734458120378556635843ActiveEducational Program/Centerhttp://bbs.yale.edufalsefalseEducation1Research2Interdepartmental Neuroscience Program1095602037855932597720378559716000Fax2ActiveProgram/Center, Genetics, and Epigenetics110442ActiveResearch Interest Care3Cancer Center, Yale109631203785409549458554764569761985547645697620ActiveProgram/Centerhttp://yalecancercenter.orgfalsefalseEducation1Research2Vascular Biology and Therapeutics Program109701ActiveProgram/Center Care3Yale Medical Group110193ActiveAdministrative Program/Centerhttp://www.yalemedicalgroup.orgfalsefalseOffice of Student Research110631ActiveEducational Program/Center Care3Yale School of Medicine113592ActiveSchoolhttp://medicine.yale.edu2From patients or physicians2Yes49Stereotactic RadiosurgeryBrain aneurysms; arterio-venous malformations (AVM); cavernous malformations; occlusive vascular disorders, carotid surgery; stereotactic radiosurgery; neurovascular intensive care unit (ICU); strokefalsetruefalsetruefalsefalsetrueAneurysm745Brain Neoplasms1842Stroke189542010-08-22T00:00:00101One gene, many disorders<p>Within the Neurogenetics program, my lab has three major research interests: the first two relate to the molecular genetics and biology of hemorrhagic stroke, focusing on brain aneurysms and cavernous malformations, and the third centers on gene discovery in developmental structural brain disorders (cerebral malformations).</p><p>The overall approach of my lab is to start with a focus on gene discovery through modern, cutting edge molecular genetics and moving on to molecular biology and functional analysis of disease in order to design diagnostics and non-invasive novel treatments.</p><p>Specialized Terms: Molecular genetics and biology of brain aneurysms and cavernous malformations; Molecular genetics of brain development<br /></p><ul> <li>Molecular Genetics of Intracranial Aneurysms </li> <li>Molecular Genetics and Biology of Cavernous Malformations </li> <li>Cerebral Malformations in Developmental Structural Brain Disorders </li> </ul> <br /><br />Aneurysm745Brain1831Genetics5573Molecular Biology8569Neurobiology9027Neurosurgery9071Hemangioma, Cavernous, Central Nervous System19189trueNixdorff-German Professor of Neurosurgery and Professor of Genetics and of Neuroscience946falseCo-Director, Yale Program on Neurogenetics944falseDirector, Neurovascular Surgery945Neurosurgery1998-06-30T00:00:00Yale-New Haven HospitalNew Haven41.308274-72.927883500000007760CTUnited StatesChief Resident1997-07-01T00:00:002185Neurosurgery1997-06-30T00:00:00Yale-New Haven HospitalNew Haven41.308274-72.927883500000007760CTUnited StatesResident1992-07-01T00:00:002187General Surgery1992-01-01T00:00:00Yale-New Haven HospitalNew Haven41.308274-72.927883500000007760CTUnited StatesIntern1991-01-01T00:00:002186599165241.302584-72.936415New Haven23438-97United States31406519CTYale Physicians Building800 Howard AvenueYale Neurosurgery3rd Floor1Patient Caretrue20373720962354Information and appointments1020378520443529Fax20542661TurkishMinimum Professional33Speaking1Minimum Professional33Reading2Minimum Professional33Writing3Minimum Professional33Overall4Bilgüvar K1, Oztürk AK, Louvi A, Kwan KY, Choi M, Tatli B, Yalnizoğlu D, Tüysüz B, Cağlayan AO, Gökben S, Kaymakçalan H, Barak T, Bakircioğlu M, Yasuno K, Ho W, Sanders S, Zhu Y, Yilmaz S, Dinçer A, Johnson MH, Bronen RA, Koçer N, Per H, Mane S, Pamir MN, Yalçinkaya C, Kumandaş S, Topçu M, Ozmen M, Sestan N, Lifton RP, State MW, Günel M. (2010) Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations.2072983116986Whole-exome sequencing identifies recessive WDR62 mutations in severe brain malformations.20101Yasuno K, Bilguvar K, Bijlenga P, Low SK, Krischek B, Auburger G, Simon M, Krex D, Arlier Z, Nayak N, Ruigrok YM, Niemela M, Tajima A, von und zu Fraunberg M, Doczi T, Wirjatijasa F, Hata A, Blasco J, Oszvald A, Kasuya H, Zilani G, Schoch B, Singh P, Stüer C, Risselada R, Beck J, Sola T, Ricciardi F, Aromaa A, Illig T, Schreiber S, van Duijn CM, van den Berg LH, Perret C, Proust C, Roder C, Ozturk AK, Gaál E, Berg D, Geisen C, Friedrich CM, Summers P, Frangi AF, State MW, Wichmann HE, Breteler MMB, Wijmenga C, Mane S, Peltonen L, Elio V, Sturkenboom MCJM, Lawford P, Byrne J, Macho J, Sandalcioglu EI, Meyer B, Raabe A, Steinmetz H, Rüfenacht D, Jääskeläinen JE, Hernesniemi J, Rinkel GJE, Zembutsu H, Inoue I, Palotie A, Cambien F, Nakamura Y, Lifton RP, Günel M: Genome-wide association study of intracranial aneurysm identifies three new risk loci. Nature Genetics, 42(5):420-5, 2010.20364137169872He Y, Zhang H, Yu L, Gunel M, Boggon TJ, Chen H, Min W: Stabilization of VEGFR2 signaling by cerebral cavernous malformation 3 is critical for vascular development. Sci Signal. 2010 Apr 6;3(116):ra2620371769169893Ercan-Sencicek G, Stillman AA, Ghosh A, Bilguvar K, O’Roak BJ, Mason CE, Abbott T, Gupta A, King RA, Pauls DL, Tischfield JA, Heiman GA, Singer HS, Gilbert DL, Hoekstra PJ, Loring E, Yasuno K, Fernandez T, Sanders S, Louvi A, Cho JH, Mane S, Colangelo CM, Biederer T, Lifton RP, Günel M and State MW. A rare dominant negative mutation in L-histidine decarboxylase implicates histaminergic neurotransmission in Tourette syndrome. New England Journal of Medicine, 362(20):1901-1908, 2010.169884Chen L, Tanriover G, Yano H, Friendlander R, Louvi A, Gunel M. (2008) Pro-apoptotic functions of PCDC10, the gene mutated in Cerebral Cavernous Malformation 3. Stroke, 40(4):1474-81, 2009.19246713140805Bilguvar K, Yasuno K, Niemelä M, Ruigrok YM, Fraunberg M, van Duijn CM, Berg LH, Mane S, Mason CE, Choi M, Gaal E, Bayri Y, Kolb L, Arlier Z, Ravuri S, Ronkainen A, Tajima A, Laakso A, Hata A, Kasuya H, Koivisto T, Rinne J, Öhman J, Breteler MMB, Wijmenga C, State MW, Rinkel GJE, Hernesniemi J, Jääskeläinen JE, Palotie A, Inoue I, Lifton RP, Gunel M. Genome-wide association identifies susceptibility loci for intracranial aneurysm in European and Japanese populations. Nature Genetics: 40, 1472 – 1477, 2008.18997786140796