Grants and contracts awarded to Yale School of Medicine

January - April 2009


  • Nadia Ameen, NIH, Functional Relevance of CFTR Trafficking in Vivo to Intestinal Disease, 4 years, $1,406,752
  • Choukri Ben Mamoun, U.S. Army Medical Research Acquisition Activity, Two New Plant-Like Pathways Link Hemoglobin Degradation to Lipid Biogenesis in Falciparum Malaria, 1 year, $228,167
  • Zubin Bhagwagar, NIH, A PET Study of 5-HT1B Receptor Binding as a Novel Biomarker for Cocaine, 1 year, $212,250
  • Linda Bockenstedt, Nat’l Research Fund for Tick-Borne Diseases, Inc., Real-Time Imaging of Vector-Borne Borrelia burgdorferi Infection in Mice, 1 year, $60,000
  • Marcus Bosenberg, NIH, The Role of Beta-Catenin Signaling in Malignant Melanoma, 1 year, $469,373
  • Martina Brueckner, NIH, Cilia in Cardiac Morphogenesis, 5 years, $2,052,375
  • David Calderwood, NIH, Integrin–Filamin Interactions in Migration and Signaling, 4 years, $1,356,968
  • Lloyd Cantley, NIH, HGF Signaling in Kidney Repair, 4 years, $1,514,326
  • Kelly Cosgrove, NIH, GABAergic Mechanisms of Comorbid Alcohol and Nicotine Dependence, 5 years, $2,504,378
  • Peter Cresswell, NIH, Molecular Aspects of Human CDld Functions, 5 years, $1,628,186
  • Alan Dardik, NIH, Molecular Regulation of Vein Graft Adaptation, 5 years, $2,399,015
  • Nihal deLanerolle, NIH, Efficacy of Erythropoietin (EPO) and EPO Analogues in the Treatment of Epilepsy, 2 years, $398,235
  • Deepak D’Souza, NIH, Imaging Nicotinic Acetylcholine Receptors in Schizophrenia, 3 years, $873,711
  • Richard Flavell, NIH, The Role of Bcl-Rambo in Thymic Involution, 5 years, $2,068,750
  • Joel Gelernter, NIH, Genetics of Alcohol Dependence in American Populations, 5 years, $3,018,367
  • David Glahn, NIH, Genetics of Brain Structure and Function, 2.5 years, $989,343; NIH, Influence of Psychosis on Brain–Behavior Endophenotypes for Bipolar Disorder, 4 years, $2,092,560; NIH, Genetics of Brain Structure and Function—Genome Wide Association, 5 years, $3,595,574
  • Danielle Guez, NIH, FACS: A Novel Method to Study Neurons Altered during Cocaine Sensitization, 3 years, $117,508
  • Shangqin Guo, NIH, MicroRNA Regulation of Stem Cell Self-Renewal, 5 years, $756,409
  • Sairy Hernandez, NIH, T B Cell Helpers in Immunity and Autoimmunity: Development, Maintenance and Migration, 3 years, $100,428
  • Mark Hochstrasser, NIH, Degradation of Short-Lived Regulatory Proteins in Yeast, 5 years, $1,807,996
  • Elizabeth Jonas, NIH, Mitochondrial Ion Channels in Hypoxic Neurons, 5 years, $2,148,484
  • Mark Kidd, NIH, Mechanisms of Abnormal Enterochromaffin Cell Secretion of Serotonin in Crohn’s Disease, 4 years, $1,331,861
  • Ami Klin, NIH, Perception of Social and Physical Contingencies in Infants with ASD, 5 years, $2,068,750
  • Patty Lee, NIH, Innate Immune Mechanisms in Emphysema, 4 years, $2,068,750
  • Elias Lolis, NIH, Regulation of CXCR4 by Cognate and Non-Cognate Ligands, 5 years, $2,049,100
  • Chao Ma, NIH, Antigen-Specific Immune Mechanisms of Neuronal Hyperexcitability and Chronic Pain, 2 years, $398,235
  • Arya Mani, NIH, The Genetics and Pathophysiology of Impaired Wnt Signaling in Metabolic Syndrome, 4 years, $1,655,000
  • Graeme Mason, NIH, Role of Acetate in Heavy Drinking, 2 years, $455,125; NIH, GABA Effects of Nicotine in Men and Women, 5 years, $1,856,250
  • Christian Matranga, NIH, Investigating the Role of RNA Helicases in RNAi and Innate Immunity, 3 years, $148,134
  • Ruslan Medzhitov, NIH, Toll Pathway and Control of Adaptive Immune Responses, 5 years, $2,105,573
  • Thomas Murray, NIH, The Regulation of Pseudomonas aeruginosa Surface Colonization, 3 years, $395,685
  • Alexander Neumeister, NIH, Serotonin 1B Receptor Imaging in PTSD with and without Comorbid Depression, 2 years, $354,772
  • Mona Nolde, NIH, The Role of Mammalian PIWI Proteins and piRNAs in Hematopoiesis and Leukemia, 3 years, $153,822
  • Chirag Parikh, NIH, Identifying Acute Tubular Necrosis in Cirrhosis Patients with Renal Dysfunction, 2 years, $455,125
  • Christopher Pittenger, NIH, Targeting Glutamate in OCD: A Placebo-Controlled, Double-Blind Augmentation Trial of Glutamate-Modulating Agent Riluzole in Treatment-Resistant OCD, 3 years, $636,750
  • Marc Potenza, NIH, International Society for Research on Impulsivity Scientific Meeting, 1 year, $39,627
  • Jennifer Prah Ruger, NIH, Economic Evaluation of Drug Abuse Treatment and HIV Prevention Services for Pregnant Women, 4 years, $2,702,314
  • Vincent Quagliarello, NIH, A Randomized Controlled Trial to Reduce Pneumonia in Nursing Home Residents, 5 years, $6,603,979
  • Mladen-Roko Rasin, NIH, Molecular Control of Corticospinal System Formation by Intermediate Targets, 2 years, $180,496
  • Matthew Roberts, NIH, Structural Insights of Postsynaptic Scaffolds and Signaling Complexes, 2 years, $82,148
  • John Rose, NIH, Novel Vaccines for Broad Protection against Avian Influenza, 4 years, $1,655,000
  • William Sessa, NIH, Endothelial NOS by Protein–Protein Interactions, 5 years, $2,431,955
  • Erik Shapiro, NIH, Magnetic Resonance Imaging of Neurogenesis, 2 years, $398,235
  • Robert Sherwin, NIH, Enhancing Clinical Investigation by Improved Clinical Research Management, 5 years, $136,160
  • Warren Shlomchik, NIH, Leukemia Stem Cells Essential Targets for GVL and Mediators of GVL-Resistance, 5 years, $1,438,520
  • Rajita Sinha, NIH, Chronic Alcohol and Brain Stress Circuit Response, 5 years, $2,606,037; Brookhaven Nat’l Laboratory, The Prefrontal Cortex in Salience and Control in Cocaine Addiction: phFMRI Study, 4 years, $136,188
  • Dieter Söll, NIH, Studies on Transfer RNA, 4 years, $6,091,595
  • David Stern, NIH, Signaling by Neuregulins and ErbB4 in Breast Cancer, 5 years, $1,758,407
  • Carlos Stocco, NIH, Molecular Pathways Controlling Ovarian Gene Expression, 5 months, $320,243
  • Vinita Takiar, NIH, Exploiting AMPK to Slow Polycystic Kidney Disease, 1 year, $45,972
  • Peter Tattersall, NIH, Molecular Genetics of ParvoviralDNAReplication, 5 years, $2,597,026
  • Flora Vaccarino, NIH, Morphogenesis and Function of the Cerebral Cortex, 5 years, $2,042,428
  • Joanne Weidhaas, NIH, Let-7 MicroRNAs in Lung Cancer: Altering Growth and Radioresistance, 5 years, $1,707,161
  • Marney White, NIH, Placebo-ControlledRCTof Bupropion for Binge Eating, 2 years, $152,400
  • Dianqing Wu, NIH, Wnt Signaling, 5 years, $1,595,961
  • Ying Xia, NIH, A New Strategy for Protection from Cerebral Ischemia, 5 years, $2,068,750

  • Vikki Abrahams, Alliance for Lupus Research, Effect of Antiphospholipid Antibodies on Trophoblast Function in Pregnancy, 16 months, $73,284
  • Ali Abu-Alfa, Genzyme Corporation, Genzyme Educational Conference, 1 year, $5,475; Abbott Laboratories Inc., Medical Education Lecture Series, 9 months, $12,000
  • Eitan Akirav, Juvenile Diabetes Research Foundation Int’l, Glucose and the Islet Vasculature: Key Players in Beta Cell Proliferation, 2 years, $91,772
  • Robert Beech, California Bipolar Foundation, Predicting Response using Expression Differences in Clinical Treatment of Bipolar Disorder (predict-BD), 1 year, $49,891
  • Choukri Ben Mamoun, Burroughs Wellcome Fund, Function and Regulation of Host and Parasite Nutrient Transporters during Malaria Infection, 2.5 years, $250,000
  • Thomas Biederer, Dana Foundation, Molecular Mechanisms Underlying the Structural Plasticity of Central Synapses, 3 years, $200,000
  • Elizabeth Bradley, William J. Clinton Foundation, Ethiopia Hospital Management, 1 year, $141,813; South Essex Partnership NHS Foundation Trust, SEPTLeadership Workshop, 6 months, $54,000
  • Judy Cho, Crohn’s & Colitis Foundation of America Inc., Mapping Rare Variants and Expression Quantitative Trait Loci Contributing to Crohn’s Disease Pathogens, 3 years, $386,100
  • Lynn Cooley, Muscular Dystrophy Association, Genetic Analysis of Muscle Function and Muscle Disease at the Single-Cell Level, 3 years, $320,000
  • Joseph Craft, Lupus Foundation of America, Mechanisms of Autoantibody Production in Lupus, 1 year, $66,000
  • Michael Crowley, Bial Foundation, When Rejection Hurts: Probing the Neural Basis of Childhood Social Exclusion with a Dense-arrayEEG, 20 months, $16,461
  • Enrique De La Cruz, American Heart Association, Nat’l Center, Mechanics of Cooperative Cofilin–Actin Filament Interactions and Severing, 5 years, $500,000
  • Linda Degutis, State of Connecticut, Yale Center for Public Health Preparedness Training and Technical Assistance, 10 months, $111,000
  • Michael DiGiovanna, Breast Cancer Alliance, Inc., Co-TargetingIGF-I Receptor andHER2 in Breast Cancer, 1 year, $100,000; Connecticut Breast Health Initiative, Inc., Combination Targeting ofIGF-I Receptor andHER2 in Breast Cancer, 1 year, $33,000
  • Ronald Duman, Repligen Corporation, Influence of Uridine on Behavior and Trophic Factor Expression in the Chronic Unpredictable Stress (CUS) Model of Depression, 1 year, $59,430
  • Marie Egan, Cystic Fibrosis Foundation, Yale–Cystic Fibrosis Therapeutics Development Center, 1 year, $64,800
  • Liana Fraenkel, Arthritis Foundation, Improving Patient Willingness to Accept Escalation of Therapy in RA, 2 years, $194,986
  • Alison Galvani, Howard Hughes Medical Institute, Workshop on Mathematical Modeling of Infectious Disease Epidemiology and Control, Durban, South Africa, 1 year, $30,000; World Health Organization, Integrated Tsetse Fly Ecology and Genetics for ImprovedHATControl, 1 year, $20,000
  • Antonio Giraldez, Muscular Dystrophy Association, The Role of MicroRNAs in Muscle Development and Muscular Dystrophy, 3 years, $401,300
  • Michael Girardi, Skin Cancer Foundation, Investigating the Immunogenomic Landscape of Cutaneous T-Cell Lymphoma, 1 year, $10,000
  • Daniel Goldstein, American Heart Association, Nat’l Center, The Interplay of Aging, Viral Immunity and Atherosclerosis, 5 years, $500,000
  • Jonathan Grauer, Stryker Spine, Biochemical Comparison of Uniaxial Screws and Monoaxial Screws, 1 year, $26,685
  • Elena Grigorenko, Florida State University, Research Supplement to Promote Diversity in Health-Related Research, 1 year, $66,129
  • Erol Gulcicek, Columbia University, Yale Proteomics Core for Biodefense, 5 years, $659,008
  • Michelle Hampson, Dana Foundation, Brain and Immuno-Imaging, 3 years, $199,482
  • Keith Hawkins, Hartford Hospital, Adolescent Maturation of Brain Network Integration for Executive Control Abilities, 6 months, $33,893
  • Kristina Herbert, Damon Runyon Cancer Research Foundation, Regulation and Mechanism of pri-miRNAprocessing by Drosha andDGCR8, 3 years, $140,000
  • Zhiwei Hu, Breast Cancer Alliance, Inc., Targeting the Tumor Blood Vessels for Photodynamic Therapy of Chemoresistant Breast Cancer, 1 year, $100,000
  • John Huang, Allergan Sales, Inc., 2008 Horizon Grants Program, 1 year, $50,000
  • Peter Jatlow, University of Connecticut Health Center, Maternal Genetics: Cigarette Smoking and Infant Birth Rate, 10 months, $9,000
  • Jing Jin, American Foundation for AIDS Research (amfAR), Cellular Factors Required forHIVCell-to-Cell Transmission, 3 years, $375,000
  • Richard Kibbey, American Diabetes Association, Inc., Characterization of Phoshpoenoylpyruvate Carboxykinase-2 as a MitochondrialGTP, 3 years, $298,350
  • Harriet Kluger, American Cancer Society, Inc., Developing an Assay to Predict Sorafenib Response in Renal Cell Carcinoma, 4 years, $900,000
  • Priti Kumar, Hanyang University, Korea, Human T Cell SpecificRNAi-Based Nano-Medicine forAIDS, 4 years, $1,114,875
  • Gregory Larkin, American Foundation for Suicide Prevention, Suicide Clusters across the Globe: Geospatial Trends from America, Ireland, and New Zealand, 2 years, $99,988
  • Csaba Leranth, Passport Foundation, Negative Effects of Bisphenol A on the Brain, 2 years, $20,000
  • William Lin, American Skin Association, Investigating the Immunogenomic Landscape of Cutaneous T-cell Lymphoma, 1 year, $7,000
  • Z. Ping Lin, Wendy Will Case Cancer Fund, Inc., Role of Ribonucleotide Reductase in Cell Cycle Checkpoints andDNADamage Repair, 1 year, $30,000
  • Thomas Lynch, American Cancer Society, Inc., YaleCancer CenterACSInstitutional Research Grant, 3 years, $420,000
  • Mark Mamula, Alliance for Lupus Research, Antigen Trafficking betweenAPCS as Therapeutic Target for Lupus, 2 years, $494,598
  • Linda Mayes, University of Maryland, Behavioral Measurement of Negative Reinforcement in Adolescent Alcohol Use/Abuse, 1 year, $12,979
  • Thomas McMahon, State of Connecticut Judicial Department, Juvenile Justice Urban Cities Pilot, 6 months, $119,526
  • Asht Mishra, Epilepsy Foundation of America, Neuroimaging Biomarkers and Prevention of Spike Wave Epileptogenesis, 1 year, $45,000
  • Deepak Narayan, Plastic Surgery Education Foundation, Spitzoid Nevi Versus Melanoma by Cellular Gp100, Nedd9, and Gab2, 1 year, $5,000
  • Elaine O’Keefe, Association of Schools of Public Health, An Introduction to Public Health Careers for Middle and High School Students, 9 months, $30,000
  • Alexander Panda, Preeclampsia Foundation, tlr Expression and Function of Peripheral Blood Immune Cells in Preeclampsia, 1 year, $25,000
  • Lynne Regan, Joan’s Legacy, Development of a Novel Class of Therapeutics for Small Cell and Non-Small Cell Lung Cancer, 2 years, $100,000
  • David Rimm, Ensemble Discovery Corporation, Proposal for Collaboration onEGFR/ERBBDimer Detection in Human Breast Cancer and Correlation with Drug Resistance, 1 year, $76,262; Susan G. Komen Breast Cancer Foundation, In Situ Detection of Cancer to Predict Non-Nodal Metastasis in Breast Cancer, 3 years, $600,000
  • Scott Rivkees, United Cerebral Palsy Research and Education Foundation, Prevention of Cerebral Palsy with Sulfonylurea Agonists, 2 years, $100,000
  • John Rose, Columbia University, Development of Novel Vaccines for High Priority Pathogens, 5 years, $1,861,875
  • David Silverman, American Heart Association, Nat’l Center, Noninvasive Assessment of Regional Changes in Perfusion during Hypovolemia andLBNP, 1 year, $22,000
  • Albert Sinusas, Massachusetts General Hospital, Absolute Quantification of Myocardial Blood Flow Using Rb-82PET, 6 months, $22,432
  • Lawrence Solomon, CT Hospice, Inc., Hospice Palliative Medicine Fellowship, 5 months, $100,000
  • Christopher Spock, Plastic Surgery Education Foundation, MicroRNAand Classification of Hemangiomas, 1 year, $10,000
  • MatthewState, University of Illinois, PETEvaluation: Tourette Syndrome, 1 year, $165,132
  • Stephen Strittmatter, Cure Alzheimer’s Fund, Specificity and Mechanism of AB-Oligomer Action through Prion Protein, 1 year, $100,000; Dr. Ralph and Marian Falk Med. Res. Trust, Axonal Regeneration Therapy for Spinal Cord Injury, 3 years, $1,119,000
  • Babak Tahvildari, Robert Leet and Clara Guthrie Patterson Trust, Functional Organization and Connectivity during Active Cortical Network, 2 years, $92,000
  • William Tamborlane, Donaghue Medical Research Foundation, Changing Life-Styles for Better Health: A Model Program for Community Health, 4 years, $926,586
  • Diana Vesely, Arthritis Foundation, Langerhans Cell Induction of T Regulatory Cells and Lyme Arthritis, 2 years, $100,000
  • Jun Yu, American Heart Association, Nat’l Center, The Role of Nogo-B on Vascular Remodeling and Atherogenesis, 4 years, $308,000
  • James Yue, Stryker Spine, Retrospective Review of Anterior Cervical Decompression and Fusion vs. Laminoplasty vs. Laminectomy for the Treatment of Cervical Myelopathy and Myeloradiculopathy, 11 months, $44,109
  • Hitten Zaveri, American Epilepsy Society, Fourth International Workshop on Seizure Prediction, 1 year, $10,000
  • Edward Zigler, Smith Richardson Foundation, Inc., Edward Zigler Center in Clinical Development and Social Policy, 2 years, $300,000
  • Howard Zonana, University of Massachusetts, An Observational Descriptive Study ofIRBPractices, 16 months, $24,000